Giant condyloma acuminatum – two cases with microinvasive foci in one

Background: Giant condyloma acuminatum (GCA) is a rare warty lesion which can be accompanied by human immunodeficiency virus (HIV) positivity and other venereal diseases and may show atypical changes in the basal layers and progress to invasive squamous cell carcinoma. Cases: Fifty-three and 55 years old two male cases of GCA are presented in this paper. The first case had multiple large, cauliflower-like cutaneous lesions in various skin sites while the other had anal lesions. Serological tests for HIV and syphilis for both patients were negative. Human papilloma virus (HPV) 6/11 were detected by in situ hybridization in the first case. HPV 6, 11, 16, 18, 31 and 33 were negative but panHPV was positive in the second case. Smear control of the wives were normal. Histologically, the first case showed only koilocytotic atypia while the other had widespread squamous cell carcinoma in situ with microinvasive foci. Conclusion: We considered these two cases were worthy to be reported, in order to emphasize that both the patients and their spouses should be evaluated with respect to HPV, HIV and other venereal diseases, and multiple samples should be examined with serial sections due to the fact that atypia and invasion may develop in these lesions.